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Study: Children’s Cytokine Response to Viruses Decrease 6 Months after Pfizer Vaccine

An Australian study published on 25 August 2023 titled “BNT162b2 COVID-19 vaccination in children alters cytokine responses to heterologous pathogens and Toll-like receptor agonists” by A. Noe et al shows that there were “sustained decreases in cytokine responses to viral, but not bacterial, stimulants six months after BNT162b2 [Pfizer] vaccination”.


Participants provided their first blood sample immediately before the first dose (V1). Then a second sample was taken 28 days after the second dose (V2 + 28). An optional third sample was taken six months after the second dose (V2 + 182). These blood samples were then used to test in vitro cytokine responses.


The study is small. But, more importantly, it begs the question as to why this was not done before the vaccine rollout. Oh wait, never mind. The median age at the time of the administration of the first dose was 6.4 years. And why are children vaccinated for a virus that generally doesn’t do much to them? Oh wait, never mind that either.


In the end, there were 29 comparisons for V1 and V2 + 28, and 8 comparisons for V1 and V2 + 182.


One of the limitations was “the inability to include an unvaccinated control group due to the ATAGI recommendation for all children aged 5 to 11 years to receive the BNT162b2 vaccine”. Well, that’s nice. I am not a doctor but whilst a comparison to an unvaccinated group is interesting, the important thing is that this study compares the pre-vaccination and post-vaccination state of each participant. In other words, it is the relative change that is important.


In short, for V1 and V2 + 28, cytokine responses to COVID seemed to increase whereas it decreased for bacterial/fungal and other viral agents (such as Hepatitis B).


Figure 2: Cytokine responses to whole‐blood stimulations 28 days after BNT162b2 vaccination. Red represents increase, blue represents decrease.
Figure 2: Cytokine responses to whole‐blood stimulations 28 days after BNT162b2 vaccination. Red represents increase, blue represents decrease.

As for V1 and V2 + 182, cytokine responses to COVID seemed to increase but there were “sustained” decreases for other viral agents. For bacterial/fungal agents, the responses seemed to stabilize.

For viral/TLR agonists (hepatitis B antigen, poly(I:C), R848) stimulations, there were decreases in several cytokine and chemokine responses in children at V2 + 182 compared to V1. Hepatitis B antigen and poly(I:C) stimulation responses were decreased for IL-6, IL-15, TNF-a, GM-CSF, PDGF-BB, VEGF, FGF-basic, IL-10, IFN-g, IL-2, IL-4, IL-5, IL-9, IL-13, and Eotaxin at V2 + 182 compared to V1. In addition, at V2 + 182 compared to V1, hepatitis B antigen stimulation responses also decreased for IL-1b, IL-12p70, IL-17, and MIP-1b. Poly (I:C) stimulation response to IL-1ra, IL-7, and MIP-1a were also decreased at V2 + 182 compared to V1. Comparison of V2 + 182 to V1 did not show any decrease in cytokine responses to R848 stimulation except for a marked increase in IL-1b (Figure 4A).

In other words, even if the so-called vaccines work for COVID-19, it seems to make children’s immune system worse for other viruses. Well, I am not a doctor but children are being “vaccinated” because because because because because…?


Figure 4: Cytokine responses to whole‐blood stimulations 182 days after BNT162b2 vaccination. (A) V1 and V2 + 182 cytokine differences, (B) the V2 + 28 and V2 + 182 cytokine differences. Red represents increase, blue represents decrease.
Figure 4: Cytokine responses to whole‐blood stimulations 182 days after BNT162b2 vaccination. (A) V1 and V2 + 182 cytokine differences, (B) the V2 + 28 and V2 + 182 cytokine differences. Red represents increase, blue represents decrease.
 

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