Study: COVID-19 Jabs Reduce Pancreatic Cancer Overall Survival
- Simian Practicalist
- Apr 24
- 2 min read
A Japanese pre-print study by M. Abue et al titled “Repeated COVID-19 Vaccination as a Poor Prognostic Factor in Pancreatic Cancer: A Retrospective, Single-Center Cohort Study” posted on 15 April 2025 supports what has been discussed by many doctors since the rollout of the so-called vaccine.
The paper is 18 pages and the main text is about 13 pages, the remaining are references.
The retrospective analysis has two cohorts. Cohort A had 272 patients with pancreatic cancer (PC) from January 2018 to November 2023, of which 223 had vaccination history information and 96 had IgG4 levels measured.
Cohort B had 79 patients from September to November 2023 to measure spike-specific antibodies, of which 16 had PC, 13 had other malignant conditions, 32 had benign conditions and 18 had IgG4-related conditions.
Two key observations were made. The first was that
[p]atient outcomes had improved each year by 2020; however, it began to deteriorate in 2021 (Figure 2a). … When divided into two groups, 0-2 vaccinations or more than two vaccinations, we found that poorer prognosis in the latter (Figure 2c).
The second is related to IgG4 which is known to be induced by COVID-19 vaccination. The researchers hypothesized that it “deteriorates the prognosis of PC patients”.
In this population, three or more vaccination group also had a poorer prognosis (Figure 3a), similar to Figure 2c. … Total IgG4 levels were significantly higher in three or more vaccination group, particularly in five or more vaccinations. When the patients were divided into two groups based on total IgG4 expression, the prognosis was significantly worse in the IgG4-high group. When the patients were divided into two groups based on OS, total IgG4 level was also significantly higher in the short OS (<90 days) group.
In short, as stated in the abstract:
The overall survival (OS) of PC patients was shortened in those vaccinated three times or more, and the total serum IgG4 levels increased with the number of vaccinations. Of note, OS was significantly shorter in the high IgG4 group, and Foxp3-positive cells in the tumor tissues were increased.
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