Study: mRNA Vaccines & Skin Conditions

An editorial by J.M. Orient titled “Negative Evidence: Cutaneous Manifestations Associated with COVID-19 mRNA Vaccination” was published in the Spring 2026 issue of Journal of American Physicians and Surgeons (Volume 31 Number 1).

The article is about 10 pages, including references. Although not a textbook, the author covers the basics of skin, its functions and common disorders before discussing possible mechanisms. The article is worth at least a skim.

Figure 1: Detailed anatomy of the skin.

Whilst many think of the skin as a mere barrier operating in a manner somewhat isolated from the rest of the body, the skin and its appendages such as hair, nails, sebaceous glands and sweat glands

…are a part of the “integumentary system” that constitutes more than a mere passive barrier. Yet they may not fully grasp all its complex physiological roles and the serious impact of dysfunctions caused by dermatological disorders. In fact, the integumentary system is the body’s largest and most dynamic super-organ. Skin is a crucial part of the [cutaneous-immuno-neuro-endocrine] CINE system: a sophisticated biological interface that keeps both local and systemic metabolic balance in response to environmental stressors.

For example, regarding endocrine and immune function, skin

…expresses CYP11A1, the enzyme that initiates steroidogenesis by converting cholesterol to pregnenolone, enabling local production of glucocorticoids (corticosterone, cortisol), sex hormones (testosterone, dihydrotestosterone, estradiol), and novel secosteroids of as yet unknown function. This steroidogenic activity varies by anatomical site and between sexes, with notable elevations in dehydroepiandrosterone in the axilla and androstenedione on the forehead. Cutaneous glucocorticoid production can be regulated by locally produced CRH, ACTH, or cytokines, and is affected by UVB radiation. … Within the skin itself, vitamin D exerts potent immunomodulatory effects. It regulates the differentiation of keratinocytes and dendritic cells, suppresses excessive T-helper 1 (Th1) and T-helper 17 (Th17) inflammatory responses, and promotes the development of regulatory T cells (Tregs) and the secretion of anti-inflammatory cytokines like interleukin-10.

The gist of it is that even though many skin conditions are not in themselves life-threatening, they maybe indicative of other serious health problems. And said problems could be caused by mRNA “vaccines”.

The author discusses various conditions and possible mechanisms. For example, regarding the commonly reported varicella zoster virus (VZV):

The leading hypothesis is “immune distraction.” The mRNA vaccine induces a massive mobilization of T-cells to respond to the Spike protein antigen. This may lead to a transient reduction in the T-cell surveillance required to keep latent VZV in check within the dorsal root ganglia, allowing the virus to reactivate and travel down the sensory nerve to the skin. Herpes zoster is a very painful condition. It is treatable with antivirals and IV vitamin C administration. However, both treatments are hard to obtain, and results may vary. The burden of pain and necessity for treatment raises questions about risk: benefit ratio of mass mRNA vaccinations.

Of course, the impact and implications of these mRNA injections are insufficiently understood and the author makes the obvious conclusion.

The fact that the mRNA platform was implemented despite those and other serious risks defies rational explanation. It should be removed from the market.

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