Study: mRNA Vaccines & Gene Alterations

An article by N. Hulscher, P.A. McCullough and J.A. Catanzaro titled “Gene Expression Alterations Induced by mRNA Vaccines” was published in the Spring 2026 issue of Journal of American Physicians and Surgeons (Volume 31 Number 1).

The article is very short, about 3 pages, briefly discussing “evidence of coordinated transcriptional and proteomic reprogramming” due to the mRNA “vaccines”. Whilst some medical professionals suspected from the beginning, there is actual data to support this.

The authors allude to a 2025 study by B. Chazarin et al as an example:

Among the 342 quantified plasma proteins, 214 demonstrated statistically significant, time-dependent modulation, with peak alterations observed between 16 and 24 weeks post-vaccination—patterns incompatible with transient inflammatory responses. The affected proteins spanned complement activation pathways and key metabolic regulators, confirming sustained engagement of immune–metabolic axes beyond short-lived innate immune signaling. Pathway enrichment analyses revealed pervasive disruptions in carbohydrate metabolism, cofactor and vitamin pathways, and endocrine signaling, underscoring systemic, gene-driven reprogramming rather than isolated acute-phase effects. In addition, shifts in autoantibody profiles targeting specific interleukins provided clear evidence of precise, mRNA-induced immunomodulatory gene expression changes.

Figure 1: Direct evidence of mRNA vaccine–induced gene expression reprogramming across transcriptomic, proteomic, and genomic levels.

The authors also mentioned the case of a 31-year-old woman who had stage IV bladder cancer within 12 months of receiving the mRNA vaccines.

Integrated profiling of circulating tumor DNA, wholeblood RNA, and exosome proteomics revealed oncogenic driver dysregulation, DNA repair deficits, and widespread molecular instability. Critically, a host–vector chimeric sequence aligning to the vaccine’s spike open reading frame (ORF) was detected in non-safe-harbor genomic regions, evidencing direct molecular interplay. In this case, oncogenic driver genes—including KRAS, PIK3CA, and ATM—exhibited markedly altered expression patterns, confirming profound transcriptional reprogramming consistent with malignant transformation.

Amongst other obvious points, the authors conclude the following:

Human data demonstrate persistent findings that indicate ongoing biological injury rather than transient, self-limited effects. Under these conditions, continued deployment constitutes an ethical breach, a failure of public-health duty, and a direct violation of the precautionary principle, which requires protective action when credible evidence indicates serious or potentially irreversible harm, even in the absence of complete mechanistic certainty. The burden of proving safety rests with the technology, not the exposed population.

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