Study: COVID-19 mRNA Vaccines Change Cornea Thickness and ECD

A study by F. Sumer and S. Subasi titled “Evaluation of the Effects of mRNA-COVID 19 Vaccines on Corneal Endothelium” published on 14 July 2025 has found that Pfizer COVID-19 mRNA injections cause changes in the cornea.

The sample is small at 64 individuals and therefore 128 eyes. The time between pre- and post-vaccination examination was about 75 days.

The significant change in the topographic evaluation was the post-vaccine (542.0 (534.25–548.0)) increase in central corneal thickness compared to pre-vaccine values (528.0 (520.25–537.75) (p = 0.001).

Whilst cornea thickness generally decreases with age and can be a problem, a sudden increase in thickness is concerning, especially when endothelial cell density was found to have decreased.

The endothelial cell density (ECD) was 2597 (2550.0–2646.50) before vaccination and 2378.0 (2299.0–2419.0) at least two months after vaccination (p < 0.001).

In addition,

[t]he mean hexagonality was 50.0 (48.25–52.0) before vaccination and 48(46–49) after vaccination (p < 0.001).

Clearly, there were measurable structural changes to the cornea after getting the jab.

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